| Characteristic | Description |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Available Dosages | 25mg, 50mg, 100mg |
| Form | Tablet |
| Usage | Treatment of erectile dysfunction |
| Onset of Action | 30 to 60 minutes |
| Duration | Up to 4 hours |
| Visit Fildena Site | |
Pharmacokinetics of Fildena
The pharmacokinetic profile of Fildena revolves around its active compound, sildenafil. This drug, administered orally, enters the bloodstream quickly. Sildenafil exhibits rapid absorption with a peak plasma concentration occurring within 30 to 120 minutes. Bioavailability stands around 40%. The presence of food, especially high-fat meals, can delay absorption.
Metabolism of sildenafil occurs primarily in the liver via the cytochrome P450 enzymes, CYP3A4 and CYP2C9. This results in the active metabolite, N-desmethylsildenafil. Both sildenafil and its metabolite contribute to the pharmacologic effect. The drug’s half-life is approximately four hours, ensuring therapeutic action lasts several hours post-dosage.
Renal excretion is not significant, with most of the compound excreted in the feces as metabolites. Understanding these pharmacokinetic characteristics assists clinicians in tailoring treatment schedules for their patients, optimizing therapeutic outcomes while minimizing risks.
Other Uses for Fildena
Fildena, primarily prescribed for erectile dysfunction, has alternative applications. Off-label, it can manage pulmonary arterial hypertension (PAH). This condition, characterized by elevated blood pressure in pulmonary arteries, benefits from sildenafil’s vasodilatory effects. This reduces vascular resistance and pressure, enhancing exercise capacity.
Clinical trials suggest potential benefits for individuals with altitude sickness. At high altitudes, oxygen levels drop, causing headaches and breathlessness. Sildenafil’s vasodilation could improve oxygen delivery. Research is ongoing for this application, yet initial findings appear promising.
Notably, Fildena is not approved for treating sexual dysfunction in women. Current evidence does not support significant efficacy in this demographic, limiting its off-label use to specific, scientifically-backed scenarios.
Fildena Contraindications
Fildena presents contraindications that demand attention. Patients with hypersensitivity to sildenafil should avoid the drug. Concurrent nitrate medication use presents a significant contraindication. Combining these agents can precipitate dangerous hypotension. Nitrates, often prescribed for angina, must be avoided with sildenafil.
Severe cardiovascular disorders, including unstable angina or severe heart failure, constitute contraindications. Physicians must weigh the benefits against potential risks in individuals with these conditions. Additionally, those with significant liver impairment may require dose adjustments or alternative therapies.
Retinitis pigmentosa, a rare genetic disorder, also contraindicates Fildena use. Its effects on vision-related enzymes could exacerbate symptoms, presenting unnecessary risks.
Pregnancy and Breastfeeding Considerations
Fildena is not recommended for pregnant women. Its safety and efficacy in pregnancy remain unstudied. Since erectile dysfunction treatments target male-specific conditions, prescribing them to pregnant women lacks justification.
The question of breastfeeding mothers requires caution. Though minimal studies exist, sildenafil presence in breast milk might affect the nursing infant. Avoiding use during lactation is prudent until further data become available.
For any patient, consulting a healthcare provider ensures informed decision-making regarding Fildena’s use in these sensitive contexts. Tailored medical advice should guide therapy initiation.
Adverse Effects of Fildena
Fildena, like any pharmacologic agent, carries potential adverse effects. Common reactions include headache, flushing, and dyspepsia. These are typically mild, resolving without intervention. Vision disturbances, such as a bluish tint or blurred vision, occur less frequently.
Less common, yet more serious, are cardiovascular events. Sudden cardiac death and myocardial infarction have been reported, predominantly in individuals with pre-existing risk factors. Priapism, a prolonged erection lasting over four hours, is a medical emergency requiring immediate attention.
Healthcare providers should remain vigilant, advising patients on symptoms that necessitate urgent care. Patient education about these potential effects enhances safety and promotes timely intervention.
Fildena for Sale Online
Purchasing Fildena online offers convenience. Yet, caution is warranted to ensure safe transactions. Selecting licensed pharmacies guarantees genuine products. Counterfeit drugs pose significant health risks. Verification of pharmacy credentials, such as accreditation and regulatory compliance, ensures authenticity.
Consulting healthcare professionals prior to online purchases is advisable. They can validate the legitimacy of online sources and provide prescriptions as needed. Fildena‘s accessibility online does not replace professional guidance. Collaboration with medical practitioners ensures both safety and efficacy.
For consumers, an informed approach to online purchasing safeguards health. As e-commerce expands, so too does the importance of informed choices. Prioritizing safety over convenience remains the cornerstone of responsible healthcare management.